Skip to main content
. 2010 Jun;24(6):1667–1681. doi: 10.1096/fj.09-136945

Figure 2.

Figure 2

Impaired number of proliferating cells in the SGL of the DG of FAD-linked APPswe/PS1ΔE9 can be rescued by experience in an enriched environment. A) APPswe/PS1ΔE9 mice exhibit significant impairments in neurogenesis. Total number of proliferating (BrdU+) cells and newly formed neurons (BrdU+/DCX+) is significantly decreased in transgenic mice harboring FAD-linked APPswe/PS1ΔE9 (APP/PS1) maintained in standard housing conditions compared with their NonTg littermates. *P = 0.0339, **P = 0.0026; Student’s t test. B) Total number of BrdU+ cells significantly increased in APP/PS1 and NonTg mice after experience in an enriched environment. Two-way ANOVA analysis shows a significant effect of housing conditions (F1,16=54.88, P<0.0001) and genotype (F1,16=10.84, P<0.01), with no significant interaction among the two parameters (F1,16=0.08642, P=0.7726), suggesting that the extent of increase in the enriched groups is comparable. Data are means ± se. *P = 0.0014, **P = 0.0004; Student’s t test. C) Representative confocal images of BrdU+ cells in the DG of mice maintained in standard housing (left) and in an enriched environment (right). Scale bar = 100 μm.