Table 4.
Functional Annotation Clusters from DAVID for Upregulated genes
| Gene Group 1. Cell Adhesion, Synaptic Transmission | |||
|---|---|---|---|
| Symbol | Gene Name | Putative function* | Fold |
| Cadm3 | cell adhesion molecule 3 | Brain specific Ca2+independent adhesion molecule involved in the formation of synapses, axon bundles and myelinated axons | 1.29 |
| Cdh1 | cadherin 1 | Regulates neuron projection growth via cadherin signaling pathway; Cdh1 cKO mice had impaired associative fear memory and exhibited impaired long-term potentiation (LTP) in amygdala slices. (Pick et al., 2013) | 1.40 |
| Clstn3 | calsyntenin 3 | Thought to be involved in signal transduction processes as vesicular trafficking protein in the brain that can couple synaptic vesicle exocytosis to neuronal cell adhesion. | 1.28 |
| Dlg4 | discs, large homolog 4 | Scaffolding protein that binds and clusters NMDA receptors at neuronal synapses; DLG4 gene disruption in mice produces a complex range of behavioral and molecular abnormalities relevant to autism spectrum disorders and Williams’ syndrome. (Feyder et al., 2010) | 1.28 |
| Kcnj4 | potassium inwardly- rectifying channel, subfamily J, member 4 | Forebrain specific with a key role in neuronal signaling by regulation of the excitability of neurons | 1.35 |
| Klk8 (neuropsin) | kallikrein related- peptidase 8 | A extracellular protease, mediates activity-dependent synaptic change required for hippocampal LTP (Ishikawa et al., 2011) | 1.43 |
| Gene Group 2. Serotonin/neurotransmitter Regulation | |||
|---|---|---|---|
| Symbol | Gene Name | Putative function* | Fold |
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | Beta 3 subunit, with alpha subunits forms active GABA-A receptors | 1.28 |
| Htr2a | 5-hydroxytryptamine (serotonin) receptor 2a | Linked to anxiety/affective disorders | 1.26 |
| Htr3a | 5-hydroxytryptamine (serotonin) receptor 3a | Ligand gated pre- and postsynaptic receptor implicated in anxiety disorders and IBS | 1.29 |
| Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | G-protein coupled receptor co-expressed with the 5-HT transporter in dorsal raphe. | 1.33 |
| Slc6a13 | solute carrier family 6 (neurotransmitter transporter, GABA), member 13 | GABA transporter (GAT2) on neurons and astrocytes | 1.27 |
| Slc6a20 | solute carrier family 6 (neurotransmitter transporter), member 20 | Amino acid transporter as part of the IMINO system. Regulates extracellular proline levels | 1.27 |
| Trh | Thyrotropin releasing hormone | Strongly implicated in anxiety, particularly in the amygdala | 1.33 |
| Gene Group 3. Other Genes implicated in Affective behaviors | |||
|---|---|---|---|
| Symbol | Gene Name | Putative Function* | Fold |
| AKAP5 | A kinase (PRKA) anchor protein 5 | AKAP5 Pro100Leu polymorphism (rs2230491) contributes to individual differences in affective control (Richter et al., 2013) | 1.36 |
| CAMK2A | calcium/calmodulin- dependent protein kinase II alpha | Significant for retrieval of fear conditioning with NMDA 2A receptors in amygdala; (Moriya et al., 2000) | 1.32 |
| WFS1 | Wolfram syndrome 1 homolog (human | Negatively related to anxiety phenotype in mice | 1.32 |
*
From NIH and RGD databases and the cited literature.