Table 2.
(a) Univariate binary logistic regression analysis for variables before mobilization associated with a poor collection (<2.5 × 106 CD34 + cells/kg), ordered by increasing P-value. (b) Multivariate analysis for all variables before mobilization found associated with a poor collection (<2.5 × 106 CD34 + cells/kg) with a P≤0.1 in univariate analysis (a), ordered by increasing P-value
| (a) | ||
|---|---|---|
|
| ||
| Variable | P-value | ORa (95% CI) |
| Platelet <100 × 106/l before mobilization | <0.001 | 2.43 (1.42–4.16) |
| G-CSF ± GM-CSF ± Epo | < 0.001 | 2.77 (1.53–5.01) |
| Chemotherapy + G-CSF | < 0.001 | 0.38 (0.22–0.65) |
| MM-CAb | < 0.001 | 0.08 (0.02–0.32) |
| Albumin <3.5g/dl | 0.003 | 2.08 (1.26–3.43) |
| Total therapy participation | 0.022 | 2.14 (1.12–4.06) |
| Bone marrow cellularity >80% | 0.029 | 0.10 (0.01–0.80) |
| Hemoglobin < 11 g/dl before mobilization | 0.032 | 1.75 (1.05–2.85) |
| Female sex | 0.047 | 1.66 (1.00–2.74) |
| Number of prior aHCTs | 0.064 | 1.41 (0.97–2.05) |
| Bone marrow cellularity <30% | 0.066 | 1.86 (0.93–3.69) |
| MDS-CAb | NS | NS |
| MDS-CA present at any time before | NS | NS |
| mobilization | ||
| Number of prior relapses | NS | NS |
| Age > 65 years | NS | NS |
| Beta-2 microglobulin > 3.5 mg/l | NS | NS |
| Time from previous aHCT | NS | NS |
| CD34 count of initial HPC collection per day | NS | NS |
| Race (Caucasian) | NS | NS |
| CD34 count of initial HPC collection | NS | NS |
| Plerixafor | NS | NS |
| Creatinine >2.0mg/dl | NS | NS |
| Plasma cell infiltration >60% | NS | NS |
| WBC <3.5 × 106/l before mobilization | NS | NS |
| CRP > 6 mg/l | NS | NS |
| Bone marrow morphology consistent with MDS |
NS | NS |
| (b) | ||
|
| ||
| Platelet <100 × 106/l before mobilization | 0.003 | 5.34 (2.39–8.01) |
| G-CSF ± GM-CSF ± Epo | 0.030 | 2.34 (1.42–4.87) |
| MM-CAb | 0.042 | 0.06 (0.02–0.54) |
| Albumin <3.5g/dl | 0.063 | 2.39 (0.87–15.7) |
| Female sex | 0.073 | 1.44 (0.92–5.85) |
| Bone marrow cellularity <30% | NS | NS |
| Total Therapy protocol participation | NS | NS |
| Hemoglobin < 11 g/dl before mobilization | NS | NS |
| Bone marrow cellularity >80% | NS | NS |
| Chemotherapy + G-CSF | NS | NS |
| Number of prior aHCTs | NS | NS |
Abbreviations: aHCT, autologous hematopoietic progenitor cell transplant; CA, cytogenetic abnormalities; CI, confidence interval; CRP, C-reactive protein; Epo, erythropoietin; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-monocyte colony-stimulating factor; HPC, hemato-poietic progenitor cell; MDS, myelodysplastic syndrome; MM, multiple myeloma; NS, not significant; OR, odds ratio; WBC, white blood cell.
The OR of a dichotomous variable for a given event represents the ratio of odds of a certain event happening when comparing the two possible outcomes. For continuous variables, the OR represents the same value for an increase of one unit of that variable. An OR > 1 represents a positive correlation of the variable with the effect of interest (higher odds for the event of interest) while an OR<1 represents an adverse one (lower odds for the event of interest).
Within 1-month before mobilization.