Table 4.

Variables significantly associated with the development of MDS-CA after a post-aHCT collection by univariate and multivariate binary logistic regression analysis (that is, P-value <0.1)

MDS-CA
Variable	P-value	ORa (95% CI)
Univariate
MDS-CA present at any time before mobilization	< 0.001	9.70 (3.78–24.8)
Prior MDS-CAb	0.009	20.6 (2.06–206)
Hemoglobin <11 g/dl before mobilization	0.016	2.74 (1.20–6.24)
Albumin <3.5g/dl	0.030	2.27 (1.11–3.03)
Poor collection (<2.5 × 106 CD34 + cells/kg)	0.035	2.59 (0.97–6.90)
CD34 count of initial HPC collection per day	0.093	0.79 (0.60–1.04)
Multivariate
MDS-CA present at any time before mobilization	< 0.001	11.6 (3.17–144)
Albumin <3.5g/dl	0.025	3.13 (1.09–8.76)
Clinical MDS/AML
Univariate
MDS-CA present at any time before mobilization	0.001	5.88 (2.04–12.34)
Albumin <3.5g/dl	0.013	4.56 (1.30–9.76)
Bone marrow cellularity<30%	0.066	2.77 (0.89–8.33)
Beta-2 microglobulin	0.074	1.01 (0.96–1.03)
CD34 count of initial HPC collection per day	0.086	0.76 (0.58–1.04)
Multivariate
Albumin <3.5g/dl	0.058	5.18 (0.94–28.4)
MDS-CA present at any time before mobilization	0.076	3.30 (0.87–12.4)

Abbreviations: aHCT, autologous hematopoietic progenitor cell transplant; CA, cytogenetic abnormalities; CI, confidence interval; Epo, erythropoietin; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-monocyte colony-stimulating factor; HPC, hematopoietic progenitor cell; MDS, myelodysplastic syndrome; OR, odds ratio; WBC, white blood cells.

^aThe OR of a dichotomous variable for a given event represents the ratio of odds of a certain event happening when comparing the two possible outcomes. For continuous variables, the OR represents the same value for an increase of one unit of that variable. An OR>1 represents a positive correlation of the variable with the effect of interest (higher odds for the event of interest) while an OR<1 represents an adverse one (lower odds for the event of interest).

^bWithin 1-month before mobilization.