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. Author manuscript; available in PMC: 2014 Jun 10.
Published in final edited form as: Nat Med. 2013 Aug 18;19(9):1132–1140. doi: 10.1038/nm.3265

Figure 5.

Figure 5

Effects of macrophage-selective siRNA knockdown of CB1R in ZDF rats, (a) Baseline blood glucose in 8-week-old ZDF rats during 10 d of treatment with scrambled (Scrb) GeRPs (gray columns and circles) or CB1R GeRPs (black columns and squares) and plasma insulin, C-peptide and pancreatic AEA levels at end of treatment, n = 6–8 rats per group; * P < 0.05, ** P < 0.01, *** P < 0.001. (b)Top, immunohistochemistry stains for islet insulin, macrophages and CB1R and Nlrp3 protein (with arrows marking antigen-positive cells). Scale bars, 50 μm. Bottom, mRNA expression of Ins1, Cd68. Cnr1, Nlrp3, Il18, Il1b, Tnf, Ccl2 and Pycard in islets isolated from ZDF rats treated with scrambled (gray) or CB1R GeRPs (black); n = 6 pergroup. * P < 0.05, ** P < 0.01, *** p < .001. Data are expressed as means ± s.e.m.