| Model | Parameter | RR | 95% CI | P |
|---|---|---|---|---|
| Unadjusted biomarker Model AUC = 0.60 (0.5398–0.6603) |
Log(Post pi-GST) | 1.410 | 1.126 −1.7653 | 0.003 |
| Adjusted for donor variables only 1 Model AUC = 0.669 (0.6108–0.7264) |
Log(Post pi-GST) | 1.284 | 1.0237 −1.6113 | 0.031 |
| Donor age (years) | 1.012 | 0.9999 −1.0248 | 0.052 | |
| Donor Black race (vs. non-Black) | 1.282 | 0.8761 −1.8745 | 0.201 | |
| DCD kidney | 1.757 | 1.2266 −2.5162 | 0.002 | |
| Donor history of hypertension | 0.852 | 0.598 −1.2127 | 0.373 | |
| Donor history of diabetes | 0.900 | 0.5447 −1.4866 | 0.680 | |
| Stroke as donor cause of death | 0.904 | 0.6319 −1.2925 | 0.579 | |
| Terminal serum creatinine (mg/dl) | 1.276 | 1.0607 −1.5353 | 0.010 | |
| Donor height (cm) | 0.991 | 0.9778 −1.0044 | 0.185 | |
| Donor weight (kg) | 1.003 | 0.9974 −1.0083 | 0.306 | |
| Adjusted for donor & transport variables2 Model AUC = 0.679 (0.6124–0.7439) |
Log(Post pi-GST) | 1.358 | 1.0525 −1.7513 | 0.019 |
| Pefusion resistance at 4 hrs (mmHg/ml/min) | 2.529 | 1.1915 −5.3666 | 0.016 | |
| Cold ischemia time (hrs) | 0.994 | 0.9646 −1.0251 | 0.716 | |
| Donor age (years) | 1.014 | 1.0002 −1.0285 | 0.047 | |
| Donor Black race (vs. non-Black) | 1.197 | 0.7649 −1.8731 | 0.431 | |
| DCD kidney | 1.715 | 1.1358 −2.5884 | 0.010 | |
| Donor history of hypertension | 0.917 | 0.6253 −1.3443 | 0.657 | |
| Donor history of diabetes | 0.938 | 0.563 −1.5624 | 0.806 | |
| Stroke as donor cause of death | 0.812 | 0.5442 −1.2103 | 0.306 | |
| Terminal serum creatinine (mg/dl) | 1.239 | 0.9987 −1.5365 | 0.051 | |
| Donor height (cm) | 0.998 | 0.9826 −1.0135 | 0.793 | |
| Donor weight (kg) | 1.001 | 0.9944 −1.0083 | 0.704 | |
| Adjusted for donor, transport & recipient variables 3 Model AUC = 0.715 (0.6539–0.7751) |
Log(Post pi-GST) | 1.363 | 1.1374 −1.6324 | 0.001 |
| Cold ischemia time (hrs) | 0.993 | 0.9694 −1.0166 | 0.547 | |
| Donor age (years) | 1.010 | 1.0 −1.0194 | 0.050 | |
| Donor Black race (vs. non-Black) | 1.238 | 0.7644 −2.0054 | 0.385 | |
| DCD kidney | 1.698 | 1.2062 −2.3897 | 0.002 | |
| Donor history of hypertension | 0.737 | 0.5289 −1.0273 | 0.072 | |
| Donor history of diabetes | 1.030 | 0.6755 −1.5712 | 0.890 | |
| Stroke as donor cause of death | 0.781 | 0.5737 −1.0619 | 0.115 | |
| Terminal serum creatinine (mg/dl) | 1.500 | 1.2189 −1.8459 | 0.000 | |
| Donor height (cm) | 0.994 | 0.9817 −1.0057 | 0.300 | |
| Donor weight (kg) | 1.001 | 0.9994 −1.0032 | 0.188 | |
| Recipient Race (Black) | 1.152 | 0.9198 −1.4421 | 0.218 | |
| Recipient male (vs. female) | 1.213 | 0.9571 −1.5382 | 0.110 | |
| Previous transplant | 1.235 | 0.8028 −1.9006 | 0.337 | |
| Diabetes as cause of ESRD | 1.105 | 0.8583 −1.4214 | 0.440 | |
| Recipient blood transfusion pre-transplant | 1.300 | 1.0141 −1.6655 | 0.059 | |
| HLA mismatches (per unit increase) | 1.257 | 1.1129 −1.4196 | 0.000 | |
| Recipient BMI (kg/m2) | 1.041 | 1.0174 −1.0642 | 0.001 | |
| Duration of dialysis (months) | 1.002 | 0.9972 −1.0058 | 0.505 |
DGF, delayed graft function; RR, relative risk; CI, confidence interval; AUC, area under the curve (regression C-statistics used for multivariable models); GST, glutathione S-transferase; DCD, donation after cardiac death; ESRD, end-stage renal disease; HLA, human leukocyte antigen; BMI, body mass index.
Donor variables used for adjustment: age in years, Black race, DCD status, hypertension, diabetes, stroke as cause of death, terminal serum creatinine in mg/dl, height in cm, and weight in kg
Includes donor variables listed above plus cold ischemia time in hours and renal resistance at 4 hours in mmHg/ml/min
Includes all variables listed above (except renal resistance) plus the following recipient variables: Black race, male gender, previous kidney transplant, diabetes as the cause of end stage renal disease, need for pretransplant blood transfusion, number of human leukocyte antigen mismatches, body mass index in kg/m2, and duration of dialysis before transplant in months