Table 1.

Cooperativity between SETD2 and PBRM1 in ccRCC.

Study	n	PBRM1	SETD2	SETD2/ PBRM1	Expected Double mutants	p value	Odds Ratio (95% CI)
Sanger Institute (16, 18)	348	111	7	8	5 (2–8)	0.16	2.3 (0.8 – 6.5)
Guo et al. (17)	98	18	1	3	1 (0–2)	0.03	12.7 (1.2 – 129)
Hakimiet al. (29)	185	48	8	6	4 (2–7)	0.24	1.9 (0.6 – 5.8)
TCGA	293	90	17	16	12 (7–14)	0.13	1.8 (0.9 – 3.7)
Total	924	267	33	33	21 (17–25)	0.003	2.1 (1.3 – 3.5)

Number of tumors with specific mutations and expected frequencies. The range of expected double mutants was calculated based on a hypergeometric distribution. Differences between actual and expected values were evaluated with a Fisher’s exact test. The Mantel-Haenszel test was used to integrate odds ratios from the different studies. KIRC TCGA data obtained from January, 2013 release. Data from the combination of these studies (the total) are highlighted in bold. Significant P values are also in bold.