Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IL-21 production controls exhaustion of CD8 T cells during chronic infection. (A) In chronic viral models, IL-21 production by CD4 T cells prevents CD8 deletion, resists attrition of polyfunctionality, ultimately resulting in viral clearance. (B) However, in the absence of IL-21 production, CD8 T cells become severely exhausted and exhibit poor polyfunctional CD8 response, resulting in poor viral control and pathogen persistence.
