Table 5.
Genes in the Streptococcus bovis / Streptococcus equinus complex identified as putative virulence factors
| Virulence factor | Gene | S. gallolyticus UCN34 | S . gallolyticus ATCC 43143 | S . gallolyticus ATCC BAA-2069 | S. pasteurianus ATCC 43144 | S. macedonicus ACA-DC 198 | S . infantarius CJ18 |
|---|---|---|---|---|---|---|---|
| Pilus 1 (pil1) |
acb |
GALLO_2179 |
SGGB_2211 |
SGGBAA2069_c21760 |
- (a) |
- |
- |
| |
sbs7 |
GALLO_2178 |
SGGB_2210 |
SGGBAA2069_c21750 |
SGPB_1938 (p) |
- |
- |
| |
srtC1 |
GALLO_2177 |
SGGB_2209 |
SGGBAA2069_c21740 |
- |
- |
Sinf_1876 |
| Pilus 2 (pil2) |
- |
GALLO_1570 |
SGGB_1568 |
SGGBAA2069_c15960 |
- |
- |
- |
| |
- |
GALLO_1569 |
SGGB_1567 |
SGGBAA2069_c15950 |
- |
- |
- |
| |
- |
GALLO_1568 |
SGGB_1566 |
SGGBAA2069_c15940 |
- |
- |
- |
| Pilus 3 (pil3) |
sbs15 |
GALLO_2040 |
SGGB_2022 |
SGGBAA2069_c19980 |
SGPB_1847 |
SMA_1939 |
Sinf_1744 |
| |
sbs14 |
GALLO_2039 |
SGGB_2021 |
SGGBAA2069_c19970 |
SGPB_1846 |
SMA_1938 |
Sinf_1743 |
| |
srtC3 |
GALLO_2038 |
SGGB_2020 |
SGGBAA2069_c19960 |
SGPB_1845 |
SMA_1937 |
Sinf_1742 |
| Cell envelope proteinase (lactocepin) |
sbs6 |
GALLO_0748 |
SGGB_0730 |
SGGBAA2069_c07210 |
- |
- |
Sinf_0588 |
| Fructan hydrolase |
sbs10 |
GALLO_0112 |
SGGB_0110 |
SGGBAA2069_c01280 |
- |
- |
- |
| Collagen adhesin |
sbs13 |
GALLO_2032 |
SGGB_2016 |
SGGBAA2069_c19910 |
SGPB_1839 (p) |
SMA_1932 (s) |
Sinf_1737 (p) |
| |
|
|
|
|
SGPB_1840 (p) |
SMA_1933 (p) |
|
| |
|
|
|
|
|
SMA_1934 (s) |
|
| Collagen adhesin |
sbs16 |
GALLO_0577 |
SGGB_0544 |
SGGBAA2069_c05110 |
- |
- |
- |
| Cell surface protein antigen C (PAc) |
- |
GALLO_1675 |
SGGB_0154 |
SGGBAA2069_c13880 |
- |
- |
- |
| |
|
|
SGGB_1687 |
SGGBAA2069_c20560 |
|
|
|
| Surrface-exposed histone-like protein A |
hlpA |
GALLO_0636 |
SGGB_0611 |
SGGBAA2069_c05790 |
SGPB_0505 |
SMA_0597 |
Sinf_0517 |
| Autolysin |
atlA |
GALLO_1368 |
SGGB_1362 |
SGGBAA2069_c13580 |
SGPB_1289 |
SMA_1299 |
Sinf_1186 (t) |
| Glucan biosynthesis gene cluster |
- |
GALLO_1052 |
- |
SGGBAA2069_c10370 |
- |
- |
- |
| |
- |
GALLO_1053 |
SGGB_1042 |
SGGBAA2069_c10380 |
- |
- |
- |
| |
rggA |
GALLO_1054 |
SGGB_1043 |
SGGBAA2069_c10390 |
- |
- |
Sinf_0876 |
| |
gtfA |
GALLO_1055 |
SGGB_1044 |
SGGBAA2069_c10400 |
- |
- |
Sinf_0877 |
| |
rggB |
GALLO_1056 |
SGGB_1045 |
SGGBAA2069_c10410 |
- |
- |
- |
| |
gtfB |
GALLO_1057 |
SGGB_1046 |
SGGBAA2069_c10420 |
- |
- |
- |
| |
sbs2/gbpC |
GALLO_1058 |
SGGB_1047 |
SGGBAA2069_c10430 |
- |
SMA_0989 (p) |
- |
| |
|
|
|
|
|
SMA_0990 (s) |
|
| |
|
|
|
|
|
SMA_0991 (s) |
|
| Hemicellulose biosynthesis gene cluster |
- |
GALLO_0364 |
SGGB_0392 |
SGGBAA2069_c03530 |
- |
SMA_0392 (p) |
Sinf_0344 |
| |
- |
GALLO_0365 |
SGGB_0393 (p) |
SGGBAA2069_c03540 (s) |
- |
SMA_0393 (p) |
- |
| |
|
|
SGGB_0394 (p) |
SGGBAA2069_c03550 (s) |
|
|
|
| |
- |
GALLO_0366 |
SGGB_0395 |
SGGBAA2069_c03560 |
- |
SMA_0394 (p) |
Sinf_0345 |
| |
|
|
|
|
|
|
Sinf_0346 (s) |
| |
- |
GALLO_0367 |
SGGB_0396 |
SGGBAA2069_c03570 |
- |
- |
- |
| Hemolysin TLY |
- |
GALLO_0630 |
SGGB_0605 |
SGGBAA2069_c05730 |
SGPB_0499 |
SMA_0591 |
Sinf_0511 |
| Hemolysin III |
- |
GALLO_1262 |
SGGB_1256 |
SGGBAA2069_c12530 |
SGPB_1172 |
SMA_1191 |
Sinf_1093 |
| Hemolysin A family protein |
- |
GALLO_1799 |
SGGB_1786 |
SGGBAA2069_c17570 |
SGPB_1603 |
SMA_1706 |
Sinf_1530 |
| Exfoliative toxin B |
- |
- |
- |
- |
- |
- |
Sinf_0933 |
| Macrophage infectivity potentiator protein | - | - | - | - | - | - | Sinf_0931 |
(a) Not found; (p) Pseudogenes; (s) Split CDSs corresponding to fragments of the original gene not yet characterized as pseudogenes; (t) Truncated.