Table 1. The SRC activity of sorted CB-derived 18Lin−CD34+/−CD133+/− cells.
Type of cells | No. of transplanted cells | % of human CD45+ cellsa (mean) | Incidence of engraftment |
---|---|---|---|
18Lin−CD34+CD133+ | 5000 | 63.1–88.0 (73.9) | 5/5 |
18Lin−CD34+CD133− | 5000 | 0 (0) | 0/6 |
18Lin−CD34−CD133+ | 5000 | 11.0–52.7 (30.4) | 5/5 |
18Lin−CD34−CD133− | 5000 | 0 (0) | 0/6 |
Abbreviations: BM, bone marrow; CB, cord blood; SRC, SCID-repopulating cell.
The human cell repopulation in the right tibia of primary recipient mice was analyzed 18 weeks after transplantation by BM aspiration.