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. Author manuscript; available in PMC: 2014 Jun 10.
Published in final edited form as: J Gene Med. 2014 Jan-Feb;16(0):11–27. doi: 10.1002/jgm.2754

Figure 1. Schematic representation of lentiviral vectors.

Figure 1

Schematic representation of A) lentiviral envelope plasmids and B) self-inactivating lentiviral expression vectors containing the ubiquitin c (Ubi-c) promoter or immunoglobulin (Ig) promoter. In the envelope vectors E2 mediates binding to target cells and E1 mediates fusion between the viral envelope and the target cell membrane. E3 and 6K are leader sequences for E2 and E1, respectively. ZZ: protein A Fc binding region; BAP: biotin adaptor protein; WRE: woodchuck hepatitis virus post-transcriptional regulatory element; ψ: packaging signal; Kappa: murine kappa light chain 3’ enhancer; IE: murine kappa light chain intronic enhancer; Ig: immunoglobulin heavy chain promoter; SIN: self-inactivating; LTR: long terminal repeat.