Table 1.
The effect of capsule piercing configuration on the mean AS device retention and aerosolization performance at the exit of the ECG cannula for five different cases as presented in Fig. 5 when the 1 liter bag was squeezed four times through 3.1–565-ECG device. The device was connected to a streamlined ECG cannula positioned at the entrance to the NGI. The standard deviation (SD) is shown in parenthesis [n=3].
| Description | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
|---|---|---|---|---|---|
| ED (%)* | 76.5 (0.9) | 79.2 (0.7) | 71.1 (1.0)** | 73.9 (2.4) | 70.9 (2.6)** |
| Capsule (%)* | 7.1 (0.5) | 6.3 (0.7) | 8.5 (0.7) | 7.5 (0.4) | 9.5 (1.6)** |
| CC (%)* | 3.3 (0.8) | 1.2 (0.1)** | 6.8 (1.0)** | 4.7 (0.7) | 7.6 (0.6)** |
| Flow passage (%) | 8.7 (0.4) | 8.8 (0.2) | 9.6 (0.6) | 9.1 (0.4) | 8.2 (0.7) |
| Connecting tubing (~1 cm) (%) | 1.8 (0.2) | 1.8 (0.1) | 1.6 (0.3) | 1.5 (0.1) | 1.6 (0.3) |
| ECG Cannula (%) | 2.6 (0.3) | 2.7 (0.2) | 2.3 (0.2) | 3.3 (2.0) | 2.1 (0.0) |
| FPF<5μm/ED (%)* | 78.1 (3.7) | 71.6 (4.6) | 83.1 (1.4) | 81.8 (4.7) | 80.4 (4.7) |
| FPF<1μm/ED (%)* | 23.7 (2.7) | 20.5 (2.3) | 30.3 (1.6) | 27.6 (3.3) | 27.7 (3.9) |
| MMAD (μm)* | 1.55 (0.06) | 1.62 (0.04) | 1.39 (0.05)** | 1.48 (0.06) | 1.45 (0.08) |
*
P<0.05 significant effect of capsule piercing on % ED, capsule and CC drug retention, FPF<5μm/ED, FPF<1μm/ED and MMAD (one-way ANOVA).
**
P<0.05 significant effect compared to Case 1 (post-hoc Tukey).