Table 3.
The effect of orifice size (3.6 mm) and capsule piercing Cases 1–3 on the mean AS device retention and aerosolization behavior at the exit of the ECG cannula actuating the 1 liter bag four times through the 3.6–565-ECG device. The DPI was connected to the streamlined ECG cannula through a 13 cm long tube (10 mm diameter) and the particle sizing was obtained using the NGI. The standard deviation (SD) is shown in parenthesis [n=3].
| Description | Case 1 | Case 2 | Case 3 |
|---|---|---|---|
| ED (%) | 51.6 (13.3) | 69.0 (0.6) | 55.6 (5.7) |
| Capsule (%) | 26.1 (15.9) | 7.8 (0.1) | 19.5 (8.5) |
| CC (%)* | 3.1 (0.4) | 0.7 (0.1)** | 3.4 (1.1) |
| Flow passage (%) | 7.1 (2.0) | 8.4 (0.3) | 9.7 (1.7) |
| Connecting tubing (13 cm) (%) | 10.1 (0.7) | 11.5 (0.3) | 9.8 (3.0) |
| ECG Cannula (%) | 1.9 (0.3) | 2.5 (0.2) | 1.9 (0.5) |
| FPF<5μm/ED (%) | 80.0 (7.3) | 73.2 (6.0) | 82.9 (1.7) |
| FPF<1μm/ED (%)* | 23.8 (2.8) | 19.5 (3.1) | 27.4 (3.0) |
| MMAD (μm) | 1.89 (0.24) | 2.20 (0.26) | 1.71 (0.09) |
*
P<0.05 significant effect of piercing configuration on % CC drug retention and FPF<1μm/ED (one-way ANOVA).
**
P<0.05 significant effect compared to Case 1 (post-hoc Tukey).