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. 2014 Apr 23;11(6):1880–1888. doi: 10.1021/mp500014r

Figure 7.

Figure 7

Effect of PDTC on the mRNA up-regulation of hPhT2/mPhT2 by LPS in THP-1 macrophages (n = 3) and mouse spleen (n = 4). THP-1 macrophages (A) were treated with LPS (10 ng/mL) for 3 h following pretreatment with PDTC (25 μM) for 1 h. PDTC suppressed the mRNA up-regulation of hPhT2, IL-6, and TNFα. ICR mice (B) were injected with LPS (1.0 mg/kg i.p.) 1 h after being pretreated with PDTC (100 mg/kg, i.p.). Samples were obtained 4 h after the LPS injection. PDTC suppressed the mRNA up-regulation of mPhT2, IL-6, and TNFα. Data are expressed by mean ± SD. Groups with different letters were statistically different as determined by one-way ANOVA and Tukey’s test.