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. 2012 Nov 8;34(25):1930–1941. doi: 10.1093/eurheartj/ehs375

Figure 4.

Figure 4

Cardiac allograft fibrosis. Intragraft transcript levels of (A) collagen type Iα1 (Col1a1) and (B) type IIIα1 (Col3a1) progressively increased with increasing grade of cardiac allograft rejection. (C–E) Intragraft transcript levels of (C) TGF-β, (D) TGF-β receptor-1 (TGF-βR1), and (E) TGF-β receptor-2 in respect to the grade of cardiac allograft rejection. (F) Sirius red stained collagen deposition with respect to the different grades of cardiac allograft rejection. (G) Representative Sirius red stained Grade 3 rejecting endomyocardial biopsies at 1 and 8 months after HTx. Scale-bar: 100 μm. (H) Cardiac allograft fibrosis is significantly increased at 8 months, when compared with 1 month after heart transplantation (*P < 0.01). *P < 0.05 vs. Grade 0 or vs. 1 month post-heart transplantation; P < 0.05 vs. Grade 1A; P < 0.05 vs. Grade 1B.