Table 2. Drugs that can cause pruritus.

Group of Drugs	Examples	Possible Mechanism
Antihypertensive Drugs	Calcium channel blockers	Xerosis, secondary to skin lesions
	Angiotensin receptor blockers	Cholestasis
	Angiotensin-converting enzyme inhibitors	Increase of bradykinin level
	Beta blockers	Secondary to skin lesions
Hypolipidemic Drugs	Statins	Xerosis
Plasma volume expanders	Hydroxyethyl starch (HES)	Deposition of HES in small peripheral nerves
Neurologic	Opioids	Central blockade of μ-opioid receptor
Antibiotics	Penicillins	Cholestasis or secondary to skin lesions
	Cephalosporins	Secondary to skin lesions
	Sulfonamides	Unknown or secondary to skin lesions
Antimalarials	Chloroquine	Unknown
Anti-cancer	Ipilimumab	Secondary to skin lesions, unknown
	EGFR inhibitors	Xerosis, secondary to skin lesions
	Bleomycin	Xerosis, secondary to skin lesions
	Tamoxifen	Sebostasis, xerosis
	Interferons
Hormone modulators	Oral contraceptives
	Androgens	Cholestasis
	Anti-androgens
Psychotropic	Lithium
	Tricyclic antidepressants	Cholestasis
Antiepileptic	Fosphenytoin	Secondary to skin lesions, allergic reaction, unknown
	Lamotrigine	Secondary to skin lesions, allergic reaction, unknown
Diuretics	Furosemide	Unknown or secondary to skin lesions
	Hydrochlorothiazide	Unknown or secondary to skin lesions
Other	Non-steroidal anti-inflammatory	Increased synthesis of leukotrienes, cholestasis
	Penicillamine
	Aspirin	Mast cell degranulation
	lodinated contrast medium	Allergic reaction, mast cell degranulation