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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: J Am Chem Soc. 2014 Jan 3;136(2):741–749. doi: 10.1021/ja410824x

Figure 1.

Figure 1

Comparison of various potential WW domain topologies. Throughout this manuscript, beta-strand 1 (the first strand from the N-terminus of the wild-type) is color-coded green, strand 2 is yellow, and strand 3 is red. Panel A represents the wild-type system. Panel B is a circular permutant with the same fold and a Trp/Trp β-capping unit substituting for the turn. Panel C represents an early folding intermediate if the order of interaction formation that has been established for the WT sequences also applies to the circularly permuted sequence.