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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: J Am Chem Soc. 2014 Jan 3;136(2):741–749. doi: 10.1021/ja410824x

Figure 4.

Figure 4

Comparison of the crystal structure of wild-type Pin1 WW domain (left, from PDB ID # 3tcz)(28) and NMR-derived structure of WW domain circular permutant WW cp29 (PDB ID # 2mdu). The EtF Trp/Trp interaction that takes the place of turn-1 is evident in the permutant structure which also has the same packing of a Trp, Tyr and Pro in the hydrophobic core. The backbone RMSD between the two structures (not counting excised loops) was 1.1 Angstroms; see Supporting Information Fig. S9 for structural overlays and more detailed comparisons.