Skip to main content
. Author manuscript; available in PMC: 2014 Jun 10.
Published in final edited form as: J Dev Biol. 2014 Mar 4;2(1):1–17. doi: 10.3390/jdb2010001

Figure 1.

Figure 1

Epicardially-derived cells contribute to the parietal leaflets of the atrioventricular (AV) valves. This figure shows a transverse section of a 17ED mouse heart from a cross between a male Wt1Cre mouse and a female R26mT/mG reporter mouse. This cell-lineage tracing model shows that the epicardially-derived cells (in red) at the AV junction (AV-EPDCs) preferentially contribute to the right parietal (rpAV) and left parietal (lpAV) leaflets of the AV valves in a mouse heart at 17 embryonic days of development. The myocardial structures are stained for the myosin heavy chain with MF20 (green), the section was counterstained with DAPI (blue in B) to stain all nuclei. AoAV = aortic leaflet of left AV valve; AS = atrial septum; LA = left atrium; LV = left ventricle; lpAV = left parietal AV valve leaflet; PuV = pulmonary vein; RA = right atrium; RV = right ventricle; rpAV = right parietal AV valve leaflet; septAV = septal leaflet of right AV valve.