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. Author manuscript; available in PMC: 2014 Jun 10.
Published in final edited form as: J Dev Biol. 2014 Mar 4;2(1):1–17. doi: 10.3390/jdb2010001

Figure 2.

Figure 2

Cascade of events involving the epicardial and epicardially-derived cells in the development of the AV junction. The epicardium plays a crucial role in virtually all aspects of the development of the structures at the AV junction. While insight into the molecular mechanisms that control the formation of the epicardium proper as well as epicardial EMT is steadily growing, virtually nothing is known about the molecular mechanisms that govern the formation of the annulus fibrosus and the ones that are involved in the migration of AV-EPDCs into the parietal AV valve leaflets.