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. 2014 Jan-Mar;10(1):29–33. doi: 10.14797/mdcj-10-1-29

Table 1.

Summary of long QT syndrome-susceptibility genes.

GENE LOCUS PROTEIN
  Long QT Syndrome
    Major LQTS Genes
    KCNQ1 (LQT1)
    KCNH2 (LQT2)
    SCN5A (LQT3) 		  11p15.5
  7q35-36
  3p21-p24		   IKs potassium channel α subunit (KvLQT1, Kv7.1)
  IKr potassium channel α subunit (HERG, Kv11.1)
  Cardiac sodium channel α subunit (Nav1.5)
    Minor LQTS Genes (listed alphabetically)
    AKAP9
    CACNA1C
    CALM1
    CALM2
    CAV3
    KCNE1
    KCNE2
    KCNJ5
    SCN4B
    SNTA1 		  7q21-q22
  12p13.3
  14q32.11
  2p21
  3p25
  21q22.1
  21q22.1
  11q24.3
  11q23.3
  20q11.2		   Yotiao
  Voltage gated L-type calcium channel (Cav1.2)
  Calmodulin
  Calmodulin
  Caveolin-3
  Kv7.1 potassium channel beta subunit (MinK)
  Kv11.1 potassium channel beta subunit (MiRP1)
  Potassium inwardly-rectifying channel (Kir3.4)
  Sodium channel beta 4 subunit
  Syntrophin-alpha 1
  Ankyrin-B Syndrome
    ANK2   4q25-q27   Ankyrin B
  Andersen-Tawil Syndrome
    KCNJ2 (ATS1)   17q23   IK1 potassium channel (Kir2.1)
  Timothy Syndrome
    CACNA1C   12p13.3   Voltage gated L-type calcium channel (CaV1.2)