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. 2014 May 21;3(5):e35. doi: 10.1038/emi.2014.35

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Microscopic lesions in neonatal gnotobiotic pigs infected with the EV71 BJ110 strain. (A) The upper panel shows a section of the lung of an orally infected gnotobiotic pig and a mock-infected control on PID 21. The infected pig has peribronchial and perivascular hemorrhage (indicated by the arrow). An adjacent alveolus contains scattered erythrocytes and macrophages (indicated by the black triangle). (B) The lower panel shows the small intestine of an oral-nasally infected gnotobiotic pig on PID 7, with a prominent presence of immune cells in the lamina propria and a significantly increased number of Peyer's patches (indicated by the asterisk). Lung tissues were stained with H&E; small intestinal tissues were sections of resin-embedded tissue stained with toluidine blue. H&E, hematoxylin and eosin.