Figure 2.

Base pharmacological network. (a) The base pharmacological network including 174 drug-induced peripheral neuropathy drugs and 280 human drug targets. The layout of the network was generated using edge-embedded spring layout available in Cytoscape, then was manually adjusted to make sure that all node names are visible. Node color represents the community structures identified by the Greedy algorithm implemented in GLay, where gray is used as a default color and nongray colors were used for the 10 biggest clusters. (b) The biggest subnetwork with 23 drugs and 62 targets, in yellow. Drugs were mostly from the antineoplastic class. (c) The second biggest subnetwork with 24 drugs and 35 targets. Drugs were mostly from antidepressive, antiparkinson, and anticonvulsant agents. Shape of notes represent types of entity: circle for drug target and rectangle for drug. The size of node corresponds to the number of interacting drugs.