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. 2014 May 14;3(5):e114. doi: 10.1038/psp.2014.11

Figure 4.

Figure 4

The best working regression model. (a) The collected clinical frequencies of the drug-induced peripheral neuropathy drugs were used in a regression tree analysis modeling using known targets and intermediators at level 5. The numbers in the yellow circles are the numbers of drugs and the numbers beneath the circles are the average incidence of these drugs. (b) The clinical information of the 17 DIPN drugs interacting with MYC alone (n = 9) or with both MYC and PAF15 (n = 8). Y and N indicate whether the corresponding drug interacts with MYC or PAF15. (c) This network includes only those drugs interacting with MYC or PAF15. The drugs within the gray boundary in the middle interact with both MYC and PAF15. The yellow nodes were not included in the regression tree modeling because we were not able to collect appropriate neuropathy incidence data from drug labels or published literature. The drugs interacting with either MYC or PAF15 are colored differently depending on the availability of the neuropathy incidence: cyan and purple for with and without available incidence, respectively.