Table 3.
The FMR1 CGG Repeats in Occult POI Women and Female Comparison Cohorts, 4 US Clinics, 2005 to 2010
| Occult POI Cohorts | Comparison Cohorts | |||||
|---|---|---|---|---|---|---|
| Pastore DOR | Streuli Occult POI15 | Streuli15 | Bretherick16 | Otsuka17 | Bodega18 | |
| Sample size | 62 | 27a | 32a | 162 | 370 | 200 |
| <35 repeats | 82.3% | 77.7% | 95.3% | 92.9% | 96.8% | 99.0% |
| 35-39 | 9.7% | 9.3% | 3.1% | 3.7% | 3.1% | |
| 40-44 | 4.8% | 7.4% | 1.6% | 1.9% | 0% | 0% |
| 45-49 | 0% | 0% | 0% | 0.9% | 0.2% | 0% |
| 50-54 | 1.6% | 0% | 0% | 0% | 0% | 1.0% |
| 55-59 | 0% | 0% | 0% | 0% | 0% | 0% |
| 60-199 | 1.6% | 5.6% | 0% | 0.9% | 0% | 0% |
| >200 | 0% | 0% | 0% | 0.9% | 0% | 0% |
Abbreviations: POI, primary ovarian insufficiency; DOR, diminished ovarian reserve.
a Data reported for both alleles in the publication, so these percentages reflect the biallelic distribution; all other columns represent the distribution of the highest allele.