Skip to main content
. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Bone. 2014 Mar 27;64:195–203. doi: 10.1016/j.bone.2014.03.041

Figure 9. Schematic of presumed consequences associated with bone marrow blood vessel ossification.

Figure 9

Extending beyond the theories presented previously that illustrates how declines in bone blood flow can modulate bone mass29, the hypothetical sequences of events presented in this investigation includes the centralized role of bone marrow blood vessel ossification and the presumed physiological and morphological consequences associated with this pathology. Several of these alterations occur with advancing age. The central role of bone marrow blood vessel ossification may provide a common mechanism linking these physiological and morphological alterations in bone and bone marrow that ultimately leads to reduced bone mass in aged individuals.