Table 2.
Relation of potential CHD risk factors to LINE-1 methylation levels among control subjects
| Potential risk factors | n | LINE-1, mean (95% CI)* | P value* |
|---|---|---|---|
| Age (tertile), years† | |||
| < 59 | 266 | 81.58 (81.33-81.83) | |
| 60-65 | 236 | 81.47 (81.22-81.72) | |
| > 65 | 286 | 81.21 (80.97-81.45) | 0.016 |
| Sex‡ | |||
| Female | 150 | 81.47 (81.14-81.81) | |
| Male | 638 | 81.40 (81.24-81.56) | 0.46 |
| Ever smoker§ | |||
| No | 590 | 81.59 (81.41-81.76) | |
| Yes | 193 | 81.05 (80.80-81.31) | 0.35 |
| Body mass index (tertile), kg/m2 | |||
| < 22.0 | 262 | 81.41 (81.16-81.66) | |
| 22.0-25.4 | 264 | 81.24 (80.99-81.48) | |
| > 25.4 | 262 | 81.58 (81.34-81.83) | 0.54 |
| Total cholesterol (tertile), mmol/L | |||
| < 2.9 | 262 | 81.83 (81.57-82.10) | |
| 2.9-4.8 | 263 | 81.57 (81.34-81.81) | |
| > 4.8 | 263 | 80.95 (80.72-81.18) | < 0.001 |
| Triglyceride (tertile), mmol/L | |||
| < 1.1 | 265 | 81.39 (81.15-81.64) | |
| 1.1-1.6 | 258 | 81.43 (81.18-81.68) | |
| > 1.6 | 263 | 81.42 (81.18-81.67) | 0.42 |
| Homocysteine (tertile), μmol/L | |||
| < 9 | 241 | 81.53 (81.26-81.80) | |
| 9-11 | 252 | 81.37 (81.12-81.63) | |
| > 11 | 254 | 81.41 (81.17-81.65) | 0.91 |
| Hypertension | |||
| No | 520 | 81.53 (81.34-81.72) | |
| Yes | 268 | 81.25 (81.03-81.47) | 0.59 |
| Diabetes | |||
| No | 638 | 81.59 (81.43-81.75) | |
| Yes | 150 | 80.85 (80.56-81.14) | < 0.001 |
CHD: Coronary heart disease; CI: Confidence interval.
*
Adjusted for age, sex, and smoking status.
†
Only adjusted for sex and smoking status.
‡
Only adjusted for age and smoking status.
§
Only adjusted for age and sex.