Table 4.
LINE-1 level in relation to CHD risk, by homocysteine level and diagnosis of hypertension
| Potential risk factors | LINE-1* | Cases, n (%) | Controls, n (%) | OR (95% CI) † |
|---|---|---|---|---|
| Homocysteine, umol/L | ||||
| < 9 | High | 24 (34.3) | 126 (52.3) | 1.0 (reference) |
| Low | 46 (65.7) | 115 (47.7) | 2.2 (1.2-4.0) | |
| 9-11 | High | 41 (38.7) | 115 (45.6) | 1.0 (reference) |
| Low | 65 (61.3) | 137 (54.4) | 1.4 (0.9-2.3) | |
| > 11 | High | 36 (24.3) | 135 (53.1) | 1.0 (reference) |
| Low | 112 (75.7) | 119 (46.9) | 3.2 (2.0-5.2) | |
| Hypertension | ||||
| No | High | 51 (39.8) | 251 (48.3) | 1.0 (reference) |
| Low | 77 (60.2) | 269 (51.7) | 1.5 (1.0-2.3) | |
| Yes | High | 53 (25.7) | 140 (52.2) | 1.0 (reference) |
| Low | 153 (74.3) | 128 (47.8) | 3.1 (2.1-4.8) | |
CHD: coronary heart disease; CI: confidence interval; OR: odds ratio.
*
The median of LINE-1 measure was based on values among control subjects. High: ≥ 81.52 (%5mC); Low: < 81.52 (%5mC).
†
Adjusted for age, sex, and smoking status.