Table 4.

Univariate and multivariate analysis regression (Cox) of predictors of death

Predictor (univariate analysis)	Hazard ratio	95% Confidence Interval (95%CI)	p value
Age > 60 years	1.0	0.7 - 1.5	0.998
Male gender	0.8	0.5 - 1.2	0.247
Etiology:
Ischemic	0.8	0.5 - 1.3	0.389
Non-ischemic (non-chagasic)	0.7	0.5 - 1.1	0.124
Chagasic	1.8	1.2 - 2.7	0.008
LVEF < 0.25	0.8	0.6 - 1.3	0.382
Anemia	1.0	0.7 - 1.6	0.939
Urea ≥ 60 mg/dL	1.7	1.1 - 2.5	0.013
Creatinine ≥ 1.4 mg/dL	1.6	1.1 - 2.4	0.013
Sodium ≤ 135 mEq/L	1.8	1.2 - 2.6	0.004
SBP < 90 mmHg	0.9	0.5 - 1.5	0.640
Medications
Inotropic agents	1.7	1.1 - 2.7	0.008
ACEI	0.6	0.4 - 0.9	0.020
Beta-blocker	0.3	0.2 - 0.5	<0.001
Losartan	1.1	0.6 - 2.0	0.788
Nitrates	1.6	1.1 - 2.4	0.017
Hydralazine	1.4	0.9 - 2.1	0.097
Digoxin	1.4	0.9 - 2.2	0.106
Spironolactone	0.7	0.4 - 1.3	0.274
Hydrochlorothiazide	1.2	0.7 - 2.0	0.483
Furosemide	1.4	0.8 - 2.4	0.205
Predictor (multivariate analysis)	Hazard ratio	95% confidence Interval	p value
Creatinine ≥ 1,4 mg/dL	2.0	1.3 - 3.0	0.002
Chagasic etiology	1.9	1.3 - 3.0	0.002
ACEI	0.6	0.4 - 0.9	0.040
Beta-blocker	0.3	0.2 - 0.5	< 0.001
Sodium ≤ 135 mEq/L	1.8	1.2 - 2.7	0.003

LVEF: left ventricular ejection fraction; SBP: systolic blood pressure; ACEI: angiotensin-converting enzyme inhibitor.