. 2014 May 19;2(4):533–538. doi: 10.3892/br.2014.280

Table IV.

Associations between genetic variants with mild and severe asthma risk.

Genotypes	Controls, (N=311) n (%)	Mild asthma (N=171) n (%)	Adjusted ORs (95% CI)	Adjusted P-values	Severe asthma (N=128) n (%)	Adjusted ORs (95% CI)	Adjusted P-values
ADAM33 (V4)
GG	214 (68.8)	76 (44.4)	1.00		55 (43.0)	1.00
GC	84 (27.0)	79 (46.2)	3.00 (1.29–6.87)^a	0.011^a	57 (44.5)	2.77 (1.15–6.66)^a	0.023^a
CC	13 (4.2)	16 (9.4)	5.99 (0.91–39.69)^a	0.063^a	16 (12.5)	8.32 (3.31–101.29)^a	0.001^a
GC/CC	97 (31.2)	95 (55.6)	3.19 (1.41–7.21)^a	0.005^a	73 (57.0)	3.81 (1.67–8.71)^a	0.002^a
ADAM33 (T2)
GG	259 (83.3)	115 (67.3)	1.00		71 (55.4)	1.00
GA	48 (15.4)	43 (25.1)	1.48 (0.57–3.81)	0.417	49 (38.3)	2.17 (0.89–5.26)	0.088
AA	4 (1.3)	13 (7.6)	3.94 (0.62–25.18)	0.147	8 (6.3)	3.16 (0.40–25.00)	0.275
ADAM33 (S2)
CC	158 (50.8)	81 (47.4)	1.00		49 (38.3)	1.00
CG	114 (36.7)	76 (44.4)	1.96 (0.85–4.55)	0.116	57 (44.5)	0.92 (0.42–2.00)	0.827
GG	39 (12.5)	14 (8.2)	22 (17.2)
ADAM33 (T1)
AA	229 (73.6)	81 (47.4)	1.00		63 (49.2)	1.00
AG	71 (22.9)	79 (46.2)	1.73 (0.73–4.10)	0.216	44 (34.4)	1.43 (0.57–3.56)	0.444
GG	11 (3.5)	11 (6.4)	0.65 (0.70–6.10)	0.706	21 (16.4)	2.03 (0.42–9.80)	0.381
TGF-β1 (T869C)
TT	110 (35.4)	65 (38.0)	1.00		52 (40.6)	1.00
CT	147 (47.3)	89 (52.0)	1.09 (0.48–2.48)	0.829	54 (42.2)	0.56 (0.24–1.33)	0.187
CC	54 (17.3)	17 (10.0)	2.18 (0.57–8.34)	0.255	22 (17.2)	2.17 (0.62–7.65)	0.227
TGF-β1 (C-509T)
CC	136 (43.7)	46 (26.9)	1.00		33 (25.8)	1.00
CT	134 (43.1)	92 (53.8)	2.73 (1.16–6.42)^a	0.022^a	68 (53.1)	2.56 (1.09–5.99)^a	0.031^a
TT	41 (13.2)	33 (19.3)	1.49 (0.43–5.09)	0.529	27 (21.1)	1.27 (0.34–4.66)	0.723
CT/TT	175 (56.3)	125 (73.1)	2.34 (1.05–5.24)^a	0.038^a	95 (74.2)	2.19 (0.98–4.93)^a	0.058^a

Adjusted for gender.

OR, odds ratio; CI, confidence interval.