Figure 3.

A schematic representation of screening and additive experiments (including rMMS). (a) An initial screen can be depicted as a cloud of points in the multidimensional crystallization space (represented here as points in three-dimensional space). (b) If a hit is obtained this can be used as the centre point of an optimization experiment (red circle) by adding small quantities of solutions from a random screen to the initial hit condition. This gives a smaller cloud of points close to the hit, increasing the chance of obtaining diffracting crystals (Shaw Stewart et al., 2011 ▶).