Table II.
Summary statistics of selected tag SNPs in the XRCC1 and XRCC3 genes and results of single-marker analysis.
| Genotype counts 11/12/22 | MAF | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Gene | SNPa | A1 | A2 | Control | Case | Control | Case | ORb | L95 | U95 | Pasym | Pemp |
| XRCC1 | rs3213282 (XRCC1.S1) | C | G | 4/35/52 | 2/11/16 | 0.2363 | 0.2586 | 1.19 | 0.53 | 2.65 | 0.6975 | 0.9899 |
| rs12611088 (XRCC1.S2) | T | C | 7/33/51 | 1/11/17 | 0.2582 | 0.2241 | 0.59 | 0.25 | 1.36 | 0.2345 | 0.6137 | |
| rs1001581 (XRCC1.S3) | A | G | 11/46/34 | 4/13/12 | 0.3736 | 0.3621 | 0.67 | 0.32 | 1.39 | 0.2900 | 0.7165 | |
| rs3213344 (XRCC1.S4) | G | C | 8/32/51 | 2/11/16 | 0.2637 | 0.2586 | 1.34 | 0.64 | 2.82 | 0.4430 | 0.8889 | |
| rs1799782 (XRCC1.S5) | T | C | 8/31/52 | 2/11/16 | 0.2582 | 0.2586 | 1.40 | 0.67 | 2.94 | 0.3833 | 0.8289 | |
| rs25487 (XRCC1.S6) | A | G | 6/35/50 | 1/13/15 | 0.2582 | 0.2586 | 0.80 | 0.36 | 1.79 | 0.6099 | 0.9705 | |
| XRCC3 | rs1799794 (XRCC3.S1) | G | A | 17/50/24 | 6/10/13 | 0.4615 | 0.3793 | 0.65 | 0.32 | 1.31 | 0.2408 | 0.5839 |
| rs861530 (XRCC3.S2) | G | A | 19/52/20 | 8/13/8 | 0.4945 | 0.5000 | 1.08 | 0.55 | 2.13 | 0.8371 | 0.9992 | |
| rs3212090 (XRCC3.S3) | A | G | 15/44/32 | 2/16/11 | 0.4066 | 0.3448 | 0.68 | 0.33 | 1.38 | 0.2959 | 0.6733 | |
| rs12432907 (XRCC3.S4) | A | G | 18/47/26 | 7/11/11 | 0.4560 | 0.4310 | 0.82 | 0.42 | 1.62 | 0.5821 | 0.9502 | |
| rs861539 (XRCC3.S5) | T | C | 1/8/82 | 0/8/21 | 0.0550 | 0.1379 | 3.88 | 1.25 | 12.07 | 0.0116c | 0.0632 | |
| rs861544 (XRCC3.S6) | T | C | 10/59/22 | 3/18/8 | 0.4341 | 0.4138 | 0.94 | 0.43 | 2.05 | 0.8795 | 0.9999 | |
a
Tag SNPs were listed down the column according to their position on the target gene from the 5′ to 3′ end of the sense strand.
b
OR was calculated using A2 as a reference.
SNP, single nucleotide polymorphism; A1, minor allele; A2, major allele; MAF, minor allele frequency; OR, odds ratio; L95, lower boundary of the 95% confidence interval; U95, upper boundary of the 95% confidence interval; Pasym, asymptotic P-value; Pemp, empirical P-value. XRCC1, X-ray repair cross-complementing protein-1; XRCC3, X-ray repair cross-complementing protein-3.