Table II.
Vascular endothelial growth factor gene polymorphisms among bladder cancer patients and healthy controls.
| SNP | Genotype | Cases, n=480 (%) | Controls, n=420 (%) | OR (95% CI) | P-value |
|---|---|---|---|---|---|
| rs833052 | CC | 278 (57.9) | 265 (63.1) | 0.80 (0.62–1.05) | 0.11 |
| CA | 156 (32.5) | 131 (31.2) | 1.06 (0.80–1.41) | 0.67 | |
| AA | 46 (9.6) | 24 (5.7) | 1.75 (1.05–2.92) | 0.03 | |
| A allele frequency | 248 (25.8) | 179 (21.3) | 1.29 (1.03–1.60) | 0.02 | |
| C allele frequency | 712 (74.2) | 661 (78.7) | 0.78 (0.62–0.97) | 0.02 | |
| rs3025039 | CC | 307 (64.0) | 284 (67.6) | 0.85 (0.64–1.12) | 0.25 |
| CT | 149 (31.0) | 121 (28.8) | 1.11 (0.84–1.48) | 0.47 | |
| TT | 24 (5.0) | 15 (3.6) | 1.42 (0.74–2.75) | 0.30 | |
| C allele frequency | 763 (79.5) | 689 (82.0) | 0.85 (0.67–1.07) | 0.17 | |
| T allele frequency | 197 (20.5) | 151 (18.0) | 1.18 (0.93–1.49) | 0.17 | |
| rs1570360 | GG | 224 (46.7) | 213 (50.7) | 0.85 (0.65–1.11) | 0.23 |
| AG | 187 (39.0) | 162 (38.6) | 1.02 (0.78–1.33) | 0.91 | |
| AA | 69 (14.3) | 45 (10.7) | 1.40 (0.94–2.09) | 0.10 | |
| G allele frequency | 635 (66.1) | 588 (70.0) | 0.84 (0.69–1.02) | 0.08 | |
| A allele frequency | 325 (33.9) | 252 (30.0) | 1.19 (0.98–1.46) | 0.08 |
SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.