Table 4. Median values for measures and biomarkers of groups defined by CRP and insulin concentration in saliva supernatant.
| Non-inflammed | Inflammed | |||||
| CRP ≤219 | CRP >219 | |||||
| Insulin ≤128 | Insulin >128 | |||||
| Clinical Measure | OH | NH | OI | NI | OC | NC |
| BMI (Kg/M2) | 26.4 *** | 16.2 | 29.8 *** | 21.4 *** | 28.2 *** | 21.1 *** |
| Waist circumference (cm) | 78.7 *** | 58.4 | 86.4 *** | 68.6 *** | 83.8 *** | 66.0 *** |
| Systolic BP (mmHg) | 121 *** | 101 | 122 *** | 113** | 120 *** | 109 *** |
| Diastolic BP (mmHg) | 78* | 70 | 84 *** | 75* | 79 *** | 72.0 |
| Fitness (beats/min) | 34.8** | 19.5 | 29.5 | 20.0 | 35.5 *** | 23.0 |
| N | 20 | 337 | 24 | 44 | 142 | 177 |
| % of total | 2.7 | 45.3 | 3.2 | 5.9 | 19.1 | 23.8 |
| % of obese | 10.8 | 12.9 | 76.3 | |||
| CRP ≤219 | CRP >219 | |||||
| Insulin ≤128 | Insulin >128 | |||||
| Biomarker | OH | NH | OI | NI | OC | NC |
| CRP (pg/ml) | 62.3 | 54.1 | 126.6** | 67.1 | 604.6 *** | 521.0 *** |
| Insulin (pg/ml) | 74.5 *** | 41.8 | 186.8 *** | 177.4 *** | 121.5 *** | 54.3 *** |
| IL-6 (pg/ml) | 3.8 | 6.2 | 3.4* | 4.6 | 8.4 *** | 10.7 *** |
| Leptin (pg/ml) | 1.3 | 0.6 | 5.7** | 0.5 | 3.3 *** | 1.4* |
| IL-10 (pg/ml) | 2.8 *** | 4.3 | 2.7* | 2.8* | 5.5* | 6.1 *** |
| Adiponectin (pg/ml) | 1201 *** | 3582 | 1872** | 1788** | 3134 | 4816** |
| Resistin (pg/ml) | 1073* | 1555 | 1116 | 948* | 1812 | 2296 *** |
| IL-1β (pg/ml) | 24.5 | 41.9 | 16.4* | 24.7* | 47.7 | 77.6 *** |
| MMP-9 (pg/ml) | 8.9* | 17.1 | 8.3* | 12.8 | 22.7* | 27.5 *** |
| IL-8 (pg/ml) | 260.5* | 440.8 | 243.4* | 259.4* | 476.7 | 644.8** |
| TNF-α (pg/ml) | 4.3* | 5.8 | 1.8** | 3.1** | 6.6 | 7.9** |
| VEGF (pg/ml) | 206.5* | 265.3 | 308.4 | 348.8** | 290.5* | 317.7* |
| IL-12P70 (pg/ml) | 13.2 | 14.7 | 8.2 | 9.3 | 9.9 | 17.5* |
| IL-17A (pg/ml) | 1.6 | 1.0 | 0* | 0.2* | 0.7 | 1.5* |
| MCP-1 (pg/ml) | 174.1* | 236.8 | 282.3 | 308.3* | 267.0* | 259.8 |
| Ghrelin (pg/ml) | 1.9 | 1.1 | 1.9 | 1.1 | 1.1 | 1.4 |
| IFNγ (pg/ml) | 3.0 | 2.2 | 1.0* | 1.3 | 1.9 | 2.6 |
| IL-13 (pg/ml) | 6.1 | 6.9 | 3.0* | 4.5* | 6.7 | 7.1 |
| MPO (pg/ml) | 26.3 | 30.7 | 25.5 | 32.5 | 30.5 | 31.7 |
| IL-4 (pg/ml) | 7.7 | 7.5 | 5.2 | 5.8 | 7.2 | 8.8 |
Categorical comparisons were by the Mann-Whitney U test. A Bonferroni correction of 0.0004 (for overall p<0.05) was applied to control the familywise error rate associated with 125 test procedures (in boldface).
***p<0.0004,
**p<0.001,
*p<0.05.