Table 3. Effects of the most significant variants in GSTP1, the GSTCD SNP rs10516526 (dominant genetic model) and the GSTT1 SNP rs2266637 (null genotype) on risk of acute myocardial infarction (AMI) and hypertension.
| Genotype frequencies | Effect estimates and precision* | |||||||
| Cases | Controls | Genetic | ||||||
| Gene: SNP | Outcome | no. (%)∧ | no. (%)∧ | Model | OR | 95% CI | p-value | |
| GSTP1: | AMI | TT | 20 (17%) | 245 (19%) | (TT+GT) vs. | 0.77 | 0.51–1.16 | 0.21 |
| rs596603 | GT | 53 (45%) | 659 (51%) | GG | ||||
| GG | 45 (38%) | 398 (30%) | ||||||
| GSTP1: | Hypertension | TT | 50 (10%) | 100 (12%) | (TT+TC) vs. | 0.66 | 0.50–0.87 | 0.003 |
| rs1871042 | TC | 201 (44%) | 406 (49%) | CC | ||||
| CC | 211 (46%) | 319 (39%) | ||||||
| GSTP1: | Hypertension | AA | 51 (11%) | 102 (12%) | (AA+AG) vs. | 0.66 | 0.50–0.88 | 0.004 |
| rs749174 | AG | 202 (43%) | 413 (49%) | GG | ||||
| GG | 213 (46%) | 326 (39%) | ||||||
| GSTP1: | Hypertension | AA | 85 (19%) | 148 (18%) | (AA+CA) vs. | 0.66 | 0.49–0.89 | 0.006 |
| rs762803 | CA | 218 (47%) | 442 (54%) | CC | ||||
| CC | 156 (34%) | 230 (28%) | ||||||
| GSTCD: | AMI | GG | 0 | 10 (1%) | (GG+AG) vs. | 0.69 | 0.34–1.38 | 0.29 |
| rs10516526 | AG | 10 (9%) | 128 (10%) | AA | ||||
| AA | 108 (91%) | 1152 (89%) | ||||||
| Hypertension | GG | 4 (1%) | 6 (1%) | (GG+AG) vs. | 0.87 | 0.55–1.36 | 0.53 | |
| AG | 50 (11%) | 78 (10%) | AA | |||||
| AA | 407 (88%) | 745 (89%) | ||||||
| GSTT1: | AMI | Null | 11 (10%) | 168 (14%) | Null vs. | 0.65 | 0.33–1.27 | 0.20 |
| rs2266637 | Non-null | 101 (90%) | 1053 (86%) | Non-null | ||||
| Hypertension | Null | 58 (13%) | 110 (14%) | Null vs. | 0.88 | 0.59–1.33 | 0.55 | |
| Non-null | 382 (87%) | 671 (86%) | Non-null | |||||
*Adjusted for age, age squared, BMI and sex.
∧
Percent of non-missing.
AMI: acute myocardial infarction, OR: odds ratio, CI: confidence interval, BMI: body mass index.