Figure 1. Activation of focal adhesion kinase occurs specifically in regions of the GBM where laminin α2 is present, and is a very early event in Alport glomerular pathogenesis.

Cryosections from 10 day old Alport mice (D–F), 7 week old Alport mice (G–I), and wild type littermates (A–C) were immunostained with antibodies specific for the α2 chain of laminin or pFAK³⁹⁷. Arrowheads denote areas of dual immunostaining in the glomerular capillary loops. Scale bar = 15 µm.