Figure 10. Treatment of Alport mice with TAE226 ameliorates interstitial fibrosis and monocyte infiltration.

Kidney cryosections from wild type and Alport mice that were either treated with vehicle or TAE226 were immunostained with antibodies specific for fibronectin (A–C or the monocyte marker, CD11b (D–F). The accumulation of fibronectin in the interstitium, indicative of fibrosis, while abundant in Alport mice (panel B) is not apparent in Alport mice treated with TAE226 (panel C), which appear similar to wild type mice (panel A). Similarly, monocyte infiltration, as indicated by CD11b immunopositive cells, is readily apparent in Alport mice (panel E). In TAE226-treated Alport mice (panel F), however, the abundance of monocytes is similar to that in wild type mice (panel D), which are resident cells rather than infiltrating cells. Scale bar = 50 µm.