Table 2. The association between longstanding or recent onset rheumatoid arthritis and 4-year incidence of cancer.

Rheumatoid arthritis	Adjustment	4-year incidence of lymphoproliferative cancer *		4-year incidence of solid cancer
No	None	1.00	0.13†	1.00	<0.0001†
Longstanding (≥3 years)		1.92 (1.08–3.39)	0.026	1.92 (1.65–2.22)	<0.0001
Recent onset (<3 years)		0.89 (0.22–3.58)	0.87	1.28 (0.96–1.72)	0.094
No	[1]	1.00	0.59†	1.00	0.33†
Longstanding (≥3 years)		1.31 (0.74–2.33)	0.35	1.10 (0.94–1.28)	0.23
Recent onset (<3 years)		0.72 (0.18–2.88)	0.64	0.88 (0.65–1.18)	0.38
No	[1], [2]	1.00	0.64†	1.00	0.26†
Longstanding (≥3 years)		1.29 (0.71–2.34)	0.41	1.10 (0.95–1.28)	0.21
Recent onset (<3 years)		0.72 (0.18–2.88)	0.64	0.86 (0.63–1.15)	0.31
No	[1], [2], [3]	1.00	0.51†	1.00	0.27†
Longstanding (≥3 years)		1.46 (0.80–2.66)	0.22	1.11 (0.96–1.30)	0.17
Recent onset (<3 years)		1.01 (0.25–4.09)	0.99	0.88 (0.65–1.19)	0.40
No	[1], [2], [3], [4]	1.00	0.66†	1.00	0.42†
Longstanding (≥3 years)		1.34 (0.73–2.44)	0.35	1.06 (0.91–1.23)	0.46
Recent onset (<3 years)		0.95 (0.23–3.88)	0.95	0.85 (0.63–1.15)	0.29

Values are odds ratios and p-values from multivariable logistic regression analyses for the development of lymphoproliferative cancer and solid tumors for the risk groups: No previous rheumatoid arthritis, Longstanding rheumatoid arthritis, and Recent onset rheumatoid arthritis. Odds ratios are adjusted in a stepwise manner: [1] sex, age (quadratic), year and month; [2] previous and present eosinophilia; [3] Charlson's Comorbidity Index, and [4] C-reactive protein. ^† P-value for the likelihood-ratio test of all categories of eosinophilia simultaneously. * Hodgkin's lymphoma, non-Hodgkin lymphoma and chronic lymphocytic leukemia.