Table 2. Change in expression of neurite inhibitory and axon growth/guidance genes 24 h following spinal cord injury at P28.
SYMBOL | GENE DESCRIPTION | FOLD |
NEURITE INHIBITION/MYELIN | ||
Efna4 | ephrin-A4 | 5.0 |
Arhgap6 | Rho GTPase activating protein 6 | 3.1 |
Gmip | GEM interacting protein encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. | 3.0 |
Novel | similar to SMPD3 sphingomyelin phosphodiesterase | 2.4 |
Novel | similar to OPHN1 oligophrenin 1,encodes Rho-GTPase-activating protein | 2.3 |
Mpz | myelin protein zero | 1.8 |
Rtn4 | Nogo, myelin inhibitory factor | 1.2 |
Mog | myelin oligodendrocyte glycoprotein | −1.7 |
Mag | myelin associated glycoprotein | −1.8 |
Arhgef10 | Rho guanine nucleotide exchange factor (GEF) 10 | −2.0 |
Arhgap35 | Rho GTPase activating protein 35 | −2.1 |
Mbp | myelin basic protein | −2.2 |
Plp1 | proteolipid protein 1 | −2.4 |
AXON GROWTH & GUIDANCE | ||
Hhipl2 | HHIP-like 2, hedgehog interacting protein-like 2 | 6.5 |
Sgsm3 | small G protein signaling modulator 3 | 4.5 |
Slit3 | slit homolog 3 (Drosophila) interacts with Robo; axon repellent | 4.0 |
Novel | similar to DNAH7 dynein, axonemal, heavy chain | 3.1 |
Robo3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 3.0 |
Mical1 | microtubule assoc monoxygenase, calponin & LIM domain containing 1 | 2.3 |
Serpinf1 | serpin peptidase inhib, clade F α-2 antiplasmin, pigment epithelium factor) | 2.3 |
Tgfb3 | transforming growth factor, β 3, regulator of ECMs and integrins | 2.2 |
Ntn5 | netrin 5 | 2.1 |
Tcerg1l | transcription elongation regulator 1-like | 2.0 |
Elmo3 | engulfment and cell motility 3 | 2.0 |
Cntn2 | contactin 2 (axonal) [Source:HGNC Symbol;Acc:2172] | −2.0 |
Sema4f | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) | −2.0 |
Astn1 | astrotactin 1, neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts, previously described in developing brain | −2.1 |
Olig2 | oligodendrocyte lineage transcrip factor 2, enhances myelination after SCI | −2.1 |
Pak7 | p21 protein (Cdc42/Rac)-activated kinase 7 | −2.3 |
Plekhb1 | pleckstrin homology domain containing, family B (evectins) member 1 | −2.4 |
Sema5a | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain TMand short cytoplasmic domain, (semaphorin) 5A | −2.4 |
Sema3e | sema domain, immunoglobulin domain (Ig), short basic domain, secreted | −2.5 |
Pak2 | p21 protein (Cdc42/Rac)-activated kinase 2 | −2.9 |
Gas7 | growth arrest-specific 7, neurite outgrowth in some cultured neurons | −7.7 |
Change in expression of neurite inhibitory and axon growth/guidance genes in rostral spinal cord 24 h following spinal cord injury at P28. Note that most of the myelin inhibitory factor genes have not changed their expression in response to injury (fold <2).