Table 3. Change in expression of extracellular matrix factor genes in 24.
SYMBOL | GENE DESCRIPTION | FOLD |
EXTRACELLULAR MATRIX | ||
Olfm4 | olfactomedin 4, also OlfD, hOlfD, ECM glycoprotein that facilitates cell adhesion. | 480 |
Mgp | matrix Gla protein | 5.1 |
Col21a1 | collagen, type XXI, alpha 1 | 4.8 |
Novel | similar to AMY cluster collagen COL25A1 | 4.3 |
Col24a1 | collagen, type XXIV, alpha 1 | 3.5 |
Lox | lysyl oxidase | 3.4 |
Ecm1 | extracellular matrix protein 1 | 3.2 |
Pxdn | peroxidasin homolog (Drosophila) | 2.9 |
Col7a1 | collagen, type VII, alpha 1 | 2.9 |
Sod3 | superoxide dismutase 3, extracellular | 2.6 |
Srrm4 | serine/arginine repetitive matrix 4 | 2.4 |
Fbn3 | fibrillin 3 | 2.3 |
Col27a1 | collagen, type XXVII, alpha 1 | 2.0 |
Col15a1 | collagen, type XV, alpha 1 | −2.0 |
Dag1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | −2.0 |
Emilin2 | elastin microfibril interfacer 2 | −2.1 |
Nfasc | neurofascin, L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains: neurite outgrowth, neurite fasciculation | −2.2 |
Nid2 | nidogen 2 (osteonidogen) binds collagens I and IV and laminin | −2.2 |
FIBRONECTIN | ||
Elfn2 | extracellular leucine-rich repeat and fibronectin type III domain containing 2 | −2.9 |
METALLOPEPTIDASES | ||
Adam11 | ADAM metallopeptidase domain 11 | 3.0 |
Adamts10 | ADAM metallopeptidase with thrombospondin type 1 motif, 10 | 2.5 |
Ermp1 | endoplasmic reticulum metallopeptidase 1 | −2.0 |
Adam17 | ADAM metallopeptidase domain 17 | −2.1 |
Cndp1 | carnosine dipeptidase 1 (metallopeptidase M20 family) | −2.2 |
METALLOPEPTIDASE INHIBITOR | ||
Timp1 | TIMP metallopeptidase inhibitor 1 | 4.4 |
METALLOTHIONINES | ||
Mmp1 | matrix metallopeptidase 1 (interstitial collagenase) | 104 |
Mmp15 | matrix metallopeptidase 15 (membrane-inserted) | −2.4 |
PROTEOGLYCANS | ||
Papln | papilin, proteoglycan-like sulfated glycoprotein | 152 |
Bcan | brevican | 2.1 |
Novel | similar to HS2ST1 heparan sulfate 2-O-sulfotransferase 1 | −2.6 |
Extl1 | exostoses (multiple)-like 1 | −3.0 |
LAMININS | ||
Lamc3 | lamin gamma 3 | 4.8 |
Lamb2 | lamini beta 2 | 2.6 |
Lamc2 | laminin gamma 2 | 2.4 |
Lamc1 | laminin gamma 1 | 2.2 |
Lama4 | laminin alpha 4 | 2.0 |
INTEGRINS | ||
Itgb1bp2 | integrin beta 1 binding protein (melusin) 2 | 6.2 |
Itga2b | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 6.1 |
Itga4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | −57 |
Change in expression of extracellular matrix (ECM) factor genes 24 h following spinal cord injury at P28, subdivided into ECM, metallopeptidases, inhibitors, proteoglycans, laminins and integrins.