Table 2.
Serum biochemistry parameters after intravenous injection of drug-unloaded NPs into the mouse
| Parameter | Control | PS-PDLLA NPs |
|---|---|---|
| TCHO (mg/dL) | 103.80±7.60 | 116.80±11.10 |
| ALT (U/L) | 32.80±10.33 | 22.80±3.56 |
| AST (U/L) | 93.60±19.63 | 105.00±58.55 |
| TP (g/dL) | 4.68±0.28 | 4.90±0.32 |
| Albumin (g/dL) | 2.08±0.26 | 2.06±0.15 |
| BUN (mg/dL) | 23.06±1.65 | 23.06±2.17 |
| Creatinine (mg/dL) | 0.38±0.30 | 0.36±0.15 |
| TBIL (mg/dL) | 0.64±0.18 | 0.56±0.11 |
| Ca2+ (mg/dL) | 9.98±0.97 | 9.28±0.28 |
| IP (mg/dL) | 6.92±2.09 | 5.10±1.39 |
Notes: NPs, at a dose of 25 mg/kg, were injected intravenously into the mouse every day for 1 week. Data are presented as means ± SD (n=5).
Abbreviations: ALT, alanine transaminase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; IP, inorganic phosphorus; TBIL, total bilirubin; TCHO, total cholesterol; TP, total protein; NP, nanoparticle; PS-PDLLA, poly(styrene)-b-poly(DL-lactide); SD, standard deviation.