Table 1. Insulin receptor signaling pathway.
| Symbol | Gene Name | LogRatio | p-value | Type(s) | Affymetrix |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 3.34 | 6.03E-05 | kinase | 1367802_at |
| IRS2 | insulin receptor substrate 2 | 2.40 | 3.27E-05 | enzyme | 1371091_at |
| INPP5B | inositol polyphosphate-5-phosphatase, 75kDa | 2.06 | 6.88E-04 | phosphatase | 1388502_at |
| FYN | FYN oncogene related to SRC, FGR, YES | 1.51 | 6.65E-05 | kinase | 1373683_at |
| IRS1 | insulin receptor substrate 1 | 1.42 | 7.73E-04 | enzyme | 1369771_at |
| INSR | insulin receptor | 1.38 | 2.96E-03 | kinase | 1392043_at |
| KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 1.15 | 7.65E-06 | enzyme | 1370035_at |
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 1.07 | 9.14E-05 | other | 1392462_at |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 1.04 | 5.22E-04 | kinase | 1386905_at |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.87 | 4.36E-04 | kinase | 1379433_at |
| PTEN | phosphatase and tensin homolog | 0.80 | 1.30E-03 | phosphatase | 1370112_at |
| SH2B2 | SH2B adaptor protein 2 | 0.78 | 2.00E-03 | other | 1368605_at |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.74 | 2.82E-03 | enzyme | 1382058_at |
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.72 | 5.38E-03 | kinase | 1370052_at |
| NCK1 | NCK adaptor protein 1 | 0.68 | 2.87E-03 | kinase | 1373940_at |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | 0.66 | 7.79E-03 | phosphatase | 1373656_at |
| GRB2 | growth factor receptor-bound protein 2 | 0.53 | 5.95E-03 | other | 1368385_a_at |
| GRB10 | growth factor receptor-bound protein 10 | 0.51 | 6.56E-03 | other | 1371517_at |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.51 | 8.78E-03 | phosphatase | 1382307_at |
| MAPK8 | mitogen-activated protein kinase 8 | 0.49 | 1.27E-03 | kinase | 1379612_at |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.48 | 3.52E-03 | other | 1389710_at |
| EIF4E | eukaryotic translation initiation factor 4E | 0.47 | 5.09E-03 | translation regulator | 1398799_at |
| SYNJ1 | synaptojanin 1 | 0.43 | 1.35E-03 | phosphatase | 1370070_at |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.37 | 5.71E-03 | enzyme | 1369157_at |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.34 | 1.37E-03 | kinase | 1369932_a_at |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.27 | 9.47E-03 | kinase | 1382366_at |
| JAK1 | Janus kinase 1 | 0.26 | 1.62E-03 | kinase | 1383478_at |
| STX4 | syntaxin 4 | -0.16 | 4.38E-03 | transporter | 1370014_at |
| FOXO4 | forkhead box O4 | -0.26 | 1.47E-03 | transcription regulator | 1372652_at |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.28 | 8.86E-03 | translation regulator | 1386970_at |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | -0.30 | 7.88E-04 | kinase | 1371578_at |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | -0.40 | 1.17E-03 | kinase | 1369655_at |
| INPPL1 | inositol polyphosphate phosphatase-like 1 | -0.41 | 7.55E-03 | phosphatase | 1368022_at |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -0.43 | 6.92E-03 | translation regulator | 1386888_at |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.48 | 1.93E-03 | phosphatase | 1373108_at |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | -0.61 | 1.31E-03 | kinase | 1388765_at |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.62 | 1.38E-03 | kinase | 1373952_at |
| INPP5K | inositol polyphosphate-5-phosphatase K | -0.64 | 1.12E-04 | phosphatase | 1373627_at |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.68 | 1.53E-04 | kinase | 1371133_a_at |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | -0.71 | 2.44E-04 | kinase | 1376190_at |
| LIPE | lipase, hormone-sensitive | -0.73 | 6.29E-03 | enzyme | 1387132_at |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.85 | 7.41E-03 | phosphatase | 1389176_at |
The cold-induced transcripts (p<0.01) of the insulin signaling pathway are shown above. The interactive relationships among the transcripts are shown in Figure 1. Based on the extent of the changes, the transcripts are listed from the highest to the lowest. Log Ratio = log2 (average cold/average control). The p-values are represented in the scientific format of Microsoft Excel (for example, 6.03E-05 = 6.03×10−05).