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Different studies testing vismodegib.
| STUDY | PHASE | PATIENTS | OR (%) | CR (%) | PR (%) | MR (MONTHS) | TOXICITY (GRADE 3 OR 4) |
|---|---|---|---|---|---|---|---|
| Lorusso et al31 | I | 33/68 | 58 | 6 | 48.5 | 12.8 | 6 patients |
| Lorusso et al32 | Ib | 67 | 30% | ||||
| Tang et al34 | II | 41 | 100 | Some | 4% | ||
| Sekulic et al32 (ERIVANCE) | II | 104 | 43 | 21 | 7.9 | ||
| Chang et al35 | 119 | 46.4% and 30.8% |
Abbreviations: OR, overall response; CR, complete response; PR, partial response; MR, median duration of response.
