Figure 1. Ischemic preconditioning (IPC) attenuates brain damage caused by middle cerebral artery occlusion (MCAO) in mice.

The time interval between preconditioning and ischemia was 24(A) Representative triphenyltetrazolium chloride-stained brain sections (1-mm thick) 24 h after MCAO in sham-operated and preconditioned mice. (B) IPC significantly reduced MCAO-induced Infarct volume compared with that in sham+MCAO controls. (C) IPC significantly attenuated MCAO-induced neurologic deficit compared with that in sham+MCAO controls. Values are expressed as mean ± SD; n = 6 per group; *p<0.05.