Skip to main content
. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Osteoarthritis Cartilage. 2014 Apr 15;22(6):726–733. doi: 10.1016/j.joca.2014.04.002

Table 3.

18-month changes in BMD from baseline per unit change in measures of body composition and leptin, D and D+E arms only.

Change in Body Weight
and Composition		 Δ Total Hip BMD
(mg/cm2)		 Δ Femoral Neck BMD
(mg/cm2)		 Δ Spine BMD
(mg/cm2)
β (95% CI) p-value β (95% CI) p-value β (95% CI) p-value
Δ Total body weight (kg) 1.9 (1.5, 2.4) <0.01 0.8 (0.3, 1.3) <0.01 0.4 (−0.3, 1.01) 0.19
Δ Total body lean mass (kg) 3.8 (2.3, 5.4) <0.01 1.4 (−0.0, 2.8) 0.06 −0.00 (−1.8, 1.8) 0.99
Δ Total body fat mass (kg) 2.8 (2.1, 3.4) <0.01 1.2 (0.5, 1.8) <0.01 0.8 (−0.0, 1.66) 0.06
Δ Leptin (ng/dL)* 1.2 (0.7, 1.7) <0.01 0.7 (0.3, 1.0) <0.01 0.6 (0.0, 1.1) 0.04
Δ Leptin (ng/dL), further adjusted
for fat mass change ** 		0.3 (−0.2, 0.8) 0.26 0.4 (0.0, 0.8) 0.05 0.5 (−0.2, 1.2) 0.14
Δ Leptin (ng/dL), further adjusted
for fat mass change ** 		0.3 (−0.2, 0.8) 0.26 0.4 (0.0, 0.8) 0.05 0.5 (−0.2, 1.2) 0.14

Model estimates adjust for randomization group, gender, baseline BMI, and baseline location BMD value.

*

Statistical significance (p<0.05) unchanged using log-leptin in model in place of leptin except for spine (log-leptin p=0.16).

**

Nonsignificance (p≥0.05) unchanged using log-leptin in place of leptin.