Skip to main content
. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Osteoarthritis Cartilage. 2014 Apr 15;22(6):726–733. doi: 10.1016/j.joca.2014.04.002

Table 4.

Change in bone mineral density by tertile* of percentage weight loss, D and D+E arms only.

Change in
BMD by Region		 Tertile 1
(n=72)		 Tertile 2
(n=73)		 Tertile 3
(n=72)		 Overall
p-value*
Mean (95% CI) Mean (95% CI) Mean (95% CI)
Δ Total Hip BMD (mg/cm2) −5.0 (−12.9, 2.9) −18.5 (−25.8, −11.2) −36.6 (−43.7, −29.5) <0.01
Δ Femoral Neck BMD
(mg/cm2)		 −6.2 (−13.7, 1.3) −8.0 (−14.9, −1.1) −21.5 (−28.2, −14.8) <0.01
Δ Spine BMD (mg/cm2) 10.1 (−4.0, 21.1) 6.8 (−5.7, 19.3) −1.7 (−13.6, 10.2) 0.37
*

Where Tertile 1 experienced <5.18% weight loss, Tertile 2 experienced ≥ 5.18% but <12.86% weight loss and Tertile 3 experienced ≥12.86% weight loss.

All tertiles for total hip achieve pairwise statistical significance (p<0.0167). Additionally, tertile 3 compared to tertiles 1 and 2 for femoral neck achieves pairwise significance.

Model estimates adjusted for randomization arm, gender, baseline BMI, and baseline regional BMD.