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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Neurobiol Learn Mem. 2014 Feb 4;112:139–147. doi: 10.1016/j.nlm.2014.01.018

Figure 2. Conditioning and CS and Context Extinction.

Figure 2

(A) Freezing to CS across conditioning trials, all groups showed greater freezing across conditioning trials, whereas chronic stress enhanced fear acquisition as evidenced by increased freezing to CS during trial 3 of conditioning (inset). (B) CS Fear Extinction. Chronic stress (STR) slowed extinction acquisition, demonstrated by increased freezing to CS midway through Extinction 1. STR also showed impaired extinction retention, with robust freezing at the beginning of Extinction 2 compared to CON. (C) Contextual Fear Extinction. STR had significantly greater contextual fear during Extinction 1 compared to CON. Data are represented as mean ± SEM; n=9–10/group. *p<0.05 vs. CON.