Table 3.
Fish Intake, Servings/Week |
No. of Cases | Person-Years of Follow-up |
Age-Adjustedb |
Multivariable Model 1c |
||
---|---|---|---|---|---|---|
RR | 95% CI | RR | 95% CI | |||
<1 | 57 | 827,311 | 1 | Reference | 1 | Reference |
1–1.9 | 109 | 1,351,974 | 1.06 | 0.76, 1.47 | 1.14 | 0.82, 1.58 |
2–2.9 | 59 | 730,667 | 0.94 | 0.65, 1.36 | 1.02 | 0.70, 1.49 |
≥3 | 62 | 601,814 | 0.95 | 0.65, 1.38 | 1.00 | 0.69, 1.47 |
P for trend | 0.90 | 0.80 |
Abbreviations: CI, confidence interval; RR, relative risk.
a Results from the cohort-specific regression models were combined using random-effects meta-analysis (for cohort-specific estimates, see Web Table 4).
b Adjusted for age (years; continuous variable) and time interval.
c Further adjusted for smoking status (never smoker, former smoker, current smoker of 1–14 cigarettes/day, current smoker of 15–24 cigarettes/day, or current smoker of ≥25 cigarettes/day), body mass index (weight (kg)/height (m)2; <25, 25–29.9, or ≥30), alcohol consumption (g/day), marital status (married/partnered, widowed, or separated/divorced/single), physical activity (metabolic equivalents/week, in quintiles), and consumption of caffeinated coffee (cups/day). For women, the multivariable regression model further adjusted for menopausal status and use of hormone replacement therapy (postmenopausal with or without hormone replacement therapy, premenopausal, or never use of hormone replacement therapy).