Table 1.
Correlations between clinicopathological parameters and Na+/K+/2Cl- cotransporter 1 expression
| Variable |
NKCC1 expression |
P value | ||
| Low grade | High grade | |||
| Age (yr) | < 60 | 12 | 10 | 0.1874 |
| ≥ 60 | 16 | 30 | ||
| Gender | Male | 25 | 32 | 0.5049 |
| Female | 3 | 8 | ||
| Location of tumor | Ce/Ut | 4 | 3 | 0.4346 |
| Mt/Lt/Ae | 24 | 37 | ||
| Tumor size (mm) | < 50 | 18 | 30 | 0.4206 |
| ≥ 50 | 10 | 10 | ||
| Histological type | Differentiated type SCC | 25 | 21 | 0.0015a |
| Poorly differentiated type SCC | 3 | 19 | ||
| pT | pT1 | 10 | 21 | 0.2191 |
| pT2-3 | 18 | 19 | ||
| pN | negative | 13 | 20 | 0.8095 |
| positive | 15 | 20 | ||
| pStage | I | 6 | 16 | 0.1231 |
| II-III | 22 | 24 | ||
| Ki-67 labeling index | 28.7 ± 2.3 | 29.9 ± 2.0 | 0.6834 | |
Ce: Cervical esophagus; Ut: Upper thoracic esophagus; Mt: Middle thoracic esophagus; Lt: Lower thoracic esophagus; Ae: Abdominal esophagus; pT: Pathological T stage; pN: Pathological N stage; pStage: Pathological stage; SCC: Squamous cell carcinoma;
a
P < 0.05 vs control, Fisher’s exact test.