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. 2014 Jun 14;20(22):6844–6859. doi: 10.3748/wjg.v20.i22.6844

Table 3.

Top biological functions, canonical pathways, and networks of Na+/K+/2Cl- cotransporter 1 according to Ingenuity Pathway Analysis

Top Biological Functions
Diseases and disorders
Name P value Number of molecules
Cancer 2.08E-12 - 1.59E-02 277
Gastrointestinal disease 8.03E-12 - 1.60E-02 149
Reproductive system disease 2.25E-09 - 1.57E-02 138
Hematological disease 1.72E-06 - 1.22E-02 70
Hereditary disorder 2.10E-06 - 1.57E-02 120
Molecular and cellular functions
Name P value Number of molecules
Cell cycle 1.06E-20 - 1.60E-02 158
Cellular assembly and organization 1.06E-20 - 1.36E-02 111
DNA replication, recombination, and repair 1.06E-20 - 1.16E-02 133
Cellular movement 8.36E-11 - 1.51E-02 82
Cell death 2.98E-06 - 1.56E-02 216
Top canonical pathways
Name P value Ratio
Role of BRCA1 in the DNA damage response 9.79E-6 12/65 (0.185)
Mitotic roles of Polo-Like kinase 7.37E-5 11/69 (0.159)
Estrogen-mediated S-phase entry 4.91E-4 6/28 (0.214)
Cell Cycle: G2/M DNA damage checkpoint regulation 5.07E-4 8/49 (0.163)
Role of CHK proteins in cell cycle checkpoint control 5.37E-4 9/56 (0.161)
Top networks
Associated network functions Score
Cellular assembly and organization; DNA replication, recombination, and repair; Cell cycle 47
Cellular assembly and organization, Cell cycle, DNA replication, recombination, and repair 43
Cell cycle; DNA replication, recombination, and repair; Cancer 37
Digestive system development and function, organismal injury and abnormalities, cellular function and maintenance 37
Cellular assembly and organization; DNA replication, recombination, and repair; Cardiovascular disease 35