Table 3.
Top biological functions, canonical pathways, and networks of Na+/K+/2Cl- cotransporter 1 according to Ingenuity Pathway Analysis
| Top Biological Functions | ||
| Diseases and disorders | ||
| Name | P value | Number of molecules |
| Cancer | 2.08E-12 - 1.59E-02 | 277 |
| Gastrointestinal disease | 8.03E-12 - 1.60E-02 | 149 |
| Reproductive system disease | 2.25E-09 - 1.57E-02 | 138 |
| Hematological disease | 1.72E-06 - 1.22E-02 | 70 |
| Hereditary disorder | 2.10E-06 - 1.57E-02 | 120 |
| Molecular and cellular functions | ||
| Name | P value | Number of molecules |
| Cell cycle | 1.06E-20 - 1.60E-02 | 158 |
| Cellular assembly and organization | 1.06E-20 - 1.36E-02 | 111 |
| DNA replication, recombination, and repair | 1.06E-20 - 1.16E-02 | 133 |
| Cellular movement | 8.36E-11 - 1.51E-02 | 82 |
| Cell death | 2.98E-06 - 1.56E-02 | 216 |
| Top canonical pathways | ||
| Name | P value | Ratio |
| Role of BRCA1 in the DNA damage response | 9.79E-6 | 12/65 (0.185) |
| Mitotic roles of Polo-Like kinase | 7.37E-5 | 11/69 (0.159) |
| Estrogen-mediated S-phase entry | 4.91E-4 | 6/28 (0.214) |
| Cell Cycle: G2/M DNA damage checkpoint regulation | 5.07E-4 | 8/49 (0.163) |
| Role of CHK proteins in cell cycle checkpoint control | 5.37E-4 | 9/56 (0.161) |
| Top networks | ||
| Associated network functions | Score | |
| Cellular assembly and organization; DNA replication, recombination, and repair; Cell cycle | 47 | |
| Cellular assembly and organization, Cell cycle, DNA replication, recombination, and repair | 43 | |
| Cell cycle; DNA replication, recombination, and repair; Cancer | 37 | |
| Digestive system development and function, organismal injury and abnormalities, cellular function and maintenance | 37 | |
| Cellular assembly and organization; DNA replication, recombination, and repair; Cardiovascular disease | 35 | |